The Toyota Sequoia is a full-size SUV manufactured by Toyota mainly for the North American market since 2000 for the 2001 model year, being derived from the Tundra pickup truck. It is the second largest SUV ever produced under the Toyota brand, after the Japan-exclusive, military-focused Mega Cruiser.

Previously manufactured at Toyota Motor Manufacturing Indiana in Princeton, Indiana between 2000 and 2021, and then in Toyota Motor Manufacturing Texas in San Antonio, Texas since 2022, the Sequoia is the first vehicle from a Japanese marque in the popular mainstream full-sized SUV class in North America, and initial planning done by first-generation Sequoia chief engineer Kaoru Hosokawa aimed the Sequoia directly at the Ford Expedition, Chevrolet Tahoe, Nissan Armada, and other full-size SUVs.

Up until the 2021 model year, the Sequoia was slotted between the mid-size 4Runner and the premium Land Cruiser in the North American Toyota SUV lineup. With the discontinuation of North American sales of the Land Cruiser from the 2022 model year onward, the Sequoia became the flagship SUV in Toyota's North America lineup.

As of 2021, the Sequoia is sold in the United States, Canada, and Costa Rica. It is offered in left-hand drive only.